TRANSLATIONAL PHYSIOLOGY Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin

نویسندگان

  • Mohammad Rajab
  • Hongwei Jin
  • Charles M. Welzig
  • Alfred Albano
  • Mark Aronovitz
  • Yali Zhang
  • Ho-Jin Park
  • Mark S. Link
  • Sami F. Noujaim
  • Jonas B. Galper
چکیده

Mohammad Rajab,* Hongwei Jin,* Charles M. Welzig,* Alfred Albano, Mark Aronovitz, Yali Zhang, Ho-Jin Park, Mark S. Link, Sami F. Noujaim, and Jonas B. Galper Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts; and Cardiovascular Division, Cardiovascular Center, Department of Medicine, Tufts Medical Center, Boston, Massachusetts

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Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin.

Although a reduction in the high-frequency (HF) component of heart rate variability (HRV) is a major complication of diabetes and a risk factor for sudden death, its relationship to ventricular tachycardia (VT) is unknown. We developed a mouse model for the study of VT and its relationship to changes in HRV in the Akita type 1 diabetic mouse. Programmed ventricular stimulation of anesthetized m...

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Predicting the eVect of D,L-sotalol on ventricular tachycardia inducibility from the RR variability response

Aim—To find a rapid way of identifying non-responders to D,L-sotalol in patients with ventricular tachycardia. Methods—Programmed ventricular stimulation and RR variability were studied in the control state and 10 days after treatment with 160 to 320 mg of D,L-sotalol in 36 consecutive patients with ventricular tachycardia. Results—In 14 patients (group I) D,Lsotalol suppressed ventricular tach...

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تاریخ انتشار 2013